Zein-Functionalized MCM-41 Silica Nanoparticles with Enzyme-Responsive for Controlled Release in Antibacterial Activity

This research provided a novel enzyme-responsive antimicrobial carrier aiming at overcoming the volatile loss of active antibacterial components, by employing mesoporous silica nanoparticles (MCM-41) as matrix encapsulation and Zein molecular gate. Since could be consumed bacteria, Zein-functionalized MCM-41 acted an gate improved controlled-release capacity. The results showed that amount capsaicin released from without bacteria was quite low compared with essential oils liberated bacteria. validated delivery hampered existence Escherichia coli (E. coli) Staphylococcus aureus (S. aureus) promoted release encapsulated cargo. rate in climbed growth velocity These functions were realized form controlled diffusion electrostatic interaction, performed both covalent bonding interaction interaction. 2.4 times more effective killing E. 1.2 inhibiting S. than equal free capsaicin, possessed long-lasting activity. responsive material might used promising preservative food industry for activity enhancement.